Bioprocess Development Internship F/H

L'entreprise

HTL Biotechnology is a French biotech and a world leader in the development and responsible bioproduction of pharmaceutical-grade biopolymers. These biopolymers are used by healthcare companies for the development of treatments in various cutting-edge therapeutic areas such as ophthalmology, dermatology, medical aesthetics and rheumatology.

For over 30 years, HTL Biotechnology has been a driving force behind innovation in the sector, collaborating with research entities and biotech companies to address unmet medical needs (regenerative medicine, drug delivery, etc.) HTL Biotechnology recently reinforced its position as world leader in the development of pharmaceutical-grade biopolymers by acquiring, through its subsidiary HTL Biotechnology Innovation Inc (HTL BII – New Jersey), a recombinant protein platform whose most advanced product is recombinant human collagen type III (rhCOL3), within a world-class scientific research center.

To meet growing global needs for biopolymers, the company has also subsidiaries in Asia and is building in the United States, a neuromodulator production unit (HTL BMI – Massachusetts). Historically based in France, the company brings together production, innovation, research and development, as well as quality activities on its site. HTL Biotechnology employs nearly 300 people worldwide.

Our ambition is to consolidate our global leadership and create value for our customers with four priorities:

• Premium positioning, by guaranteeing a high level of product quality and safety
• Innovation, by driving research in the biopolymers sector.
• International expansion, by placing production and R&D at the service of new markets and customers.
• Social responsibility, through which we aim to transform the biopolymer sector into a positive, sustainable force.

To learn more about HTL Biotechnology: https://htlbiotech.com/

Description du poste

In our New Jersey lab, HTL Biotechnology Innovation Inc (HTL-BII), we are focused on the development of recombinant collagen-like proteins within our world-class scientific research center. Our most advanced product, recombinant human collagen type III (rhCOL3), is a biocompatible and sustainable biomolecule with applications in fields such as ophthalmology, dermatology, medical aesthetics, and biomaterials. 

Our internal capabilities and processes include 

•    Molecular biology – AI-based gene design, libraries of plasmid and background strain, DNA construction, Gene editing by CRISPR, Next generation sequencing (Illumina sequencer), high-throughput screening (Qpix clone picker, BioLector micro fermenters)
•    Biochemistry – Centrifugation, chromatograph purification (AKTA), enzymatic reaction
•    Fermentation – Fermenters from 200 ml (DASbox® Mini Bioreactor System) to 5L, 10 L and 200 L (Sartorius)
•    Downstream processing – Pilot scale purification at 20 L and 200 L (disc stack centrifuge, filtration system, bead mill, chromatography etc.)
•    Analytical assays – Protein electrophoresis, fluorescent imaging system, plate-based assays (ELISA), analytical HPLC, UPLC, GC Mass Spec, LC Mass Spec, CD (circular dichroism), microscope (including EM), Nano DSC etc.
•    Mammalian cell culture – Mammalian cell culture, viability and cytotoxicity assays and specific ECM protein assays

In summary, HTL BII offers a unique opportunity for interns to learn molecular biology, biochemistry, fermentation, downstream processing in an integrated platform with a clear commercial goal.

Role: 

We are looking for a motivated DSP Process Development Intern for Summer 2025 to assist in the development and optimization of our bioprocess platform for recombinant protein production. During this internship, you will be a part of an experienced team of multi-disciplinary scientists working on the cutting-edge of biopolymer and recombinant protein research.  

Responsibilities:
•    Gain hands on experience on chromatography and filtration systems for protein purification. 
•    Prepare, assemble, clean, and sterilize glassware and laboratory equipment for research and production activities.
•    Accurately weigh and log formulations for DSP processes.
•    Conduct sample preparations and support analytical measurement activities.
•    Organize and maintain inventory of consumables, in process samples, and final product.
•    Help Research Scientists and Engineers with experiment execution for R&D projects.
•    Provide timely and accurate verbal and written communication to team members on assigned responsibilities.
•    Able to use Microsoft Excel to perform basic calculations, such as determining concentrations or combining weights and volumes of sample.

Profil recherché

Requirements :

•    Currently pursuing a Bachelor’s or Master’s degree in Chemical Engineering, Bioprocess Engineering, Biochemistry, or related field
•    Prior lab experience (academic or research) is recommended
•    Basic knowledge of bioproduction 
•    Proficient with Microsoft Office, particularly Excel
•    Possess the ability to work in a fast-paced and interdisciplinary environment
•    Team-player with strong communication skills
•    Strong problem-solving, analytical, and organizational skills

Why Join HTL? 

•    Gain hands-on lab experience in a leading biotech company with cutting-edge bioprocess techniques.
•    Work in a collaborative, international research environment driving real-world medical innovations.
•    Be part of groundbreaking advancements in recombinant collagen and biopolymer applications.
•    Build a strong foundation for your future career in biotechnology and pharmaceuticals.
How to apply 

Réf: 149e8cd9-2364-45b0-be8a-fccbb85e1c68